Gas bloting, acid reflux and irregular bowel movement required me to take Zantac. I also suffer from severe asthma. After about a week of Zantac treatment, I realized that I was unable to get an erection, and lacked any sexual desire, even when stimulated by my female partner. This was devastating. I am in my early 40s, and have always been sexually active. I research the internet for possible ED symptons, and found out that prolonged use of Zantac can adversely affect an erection. I have now resorted to Pantoloc, instead of Zantac and hope to enjoy my relations with my partner once again. No more Zantac for me.