I am a 53 year old RN, who is pretty much up to date on medications. I have been given Levaquin IV for Crohn's flare ups, but since my surgery 4 years ago, I have been fine. I have taken it orally once before, no problems. Last week after being on Macrobid for a few days and it not working, my pcp Rx this. I almost immediately started having a gerneralized adverse reaction, shortness of breath, elevated pulse and dizziness, felt as if I would faint. It passed, and as I wasn't expecting a reaction, I was certain I was not imagining it. I went to this site and was pretty concerned, but continued taking it as I know the power of suggestion and usually dismiss "drug paranoia". Big mistake! I now have pain all over my body. All the major muscle groups are hurting. Bruising all over my legs, and insomnia. Since I already take an RX for sleep, I'm sure it is the Levaquin. I pray I do not get worse, as this is bad enough. I'm sure my PCP will tell me I'm nuts, Docs are the absolute worse. I should probably go see the nurse practitioner, might have a better chance with a nurse. Just adding my 2 cents, and if I keep one other person from taking it this is worth the time, though I work on line all the time, with no problems, my wrists are hurting as well! In the past I had a reaction to Cipro, but nothing ever this bad. The new bugs out there are all becoming immune to regular antibiotics, and if you have a UTI like I have you can get pretty desperate. DON"T EVER take this for a simple sinus infection! I would rather have headaches all day. Sinus infections eventually clear up.