I have been prescribed Doxycycline 100mg twice daily for suspected Lyme disease. I have never experienced such strong side effects from taking an antibiotic before! The morning dose is the worst by far for me. It makes me feel incredibly nauseous and it makes me feel hot with stomach pains. I feel like being sick all the time for about 3-4 hours after taking it - I have tried lots of water and food but I still feel like crap! After about 4 hours I start to feel a little better then I feel like eating lots and lots!!! My body just seems to be swinging from feeling like I am dying to being very hungry hours later... I take the last pill about 10pm and stay downstairs for about a hour before I go to bed - strangely enough though I have never felt ill like I do in the morning and go to sleep ok. All very weird and I cant wait until I have finished taking this drug (14 day course and I am half way through)