My son ,23 months old, started on Singulair this past spring 06, after pulmicort wasnt doing the trick at taking away his sick asthma. Singulair has worked thus far, but I have noticed if I forget to give it to him, the next day he is irritable and miserable. It doesnt seem coincidental anymore because over the summer I tried cutting back a little on the meds because typically illnesses occur during the winter months. And he seemed to be more irritable every time i cut back. I will be going to his specialist soon and discuss this with him. Hopefully we have a better winter this year and he can be off all his meds soon. Also, he will not go to sleep if I give it to him at night, I use it after his afternoon naptime.