28 y/o male. I have used advair on and off for three years. I started on 100/50 twice a day and eventually reduced to once a day. Right now I am trying to wean myself off it completely; I haven't had a dose in 48 hours. I have been on some kind of inhaled corticosteroids for asthma since early childhood. I never had any issue with weight gain. The side effects I noticed with Advair have occasional heart palpitations and dizzyness, and loosing my voice. Since I have to speak publicly because of my job, the voice loss has been the worst. I wouldn't describe it as horseness, but rather a sort of vocal weakness or wateryness. I normally have a fairly deep, loud voice, and it comes back within 48 hours of discontinuing the advair. I tried every method of rinsing out my throat and mouth to avoid the voice loss, to no avial. As I said above, I have been 48 hours without a dose, and I feel fine. Wish me luck. I'm interested to see if I can make it without the steroids...its been over 20 years.