i have been on and off advair since 2002. it is very effective for its intended purpose;the relief from asthmatic symptoms.however i always got a hoarse voice(even with thorough rinsing) and shortly after, my speech would become slurred. I cant be sure,but headaches,dizziness and high blood pressure also seem to be side effects. all the side effects quickkly go away (a few days) when i discontinue its use. at this point i prefer to live with the asthma.