I am having surgery in two weeks (laparascopy, hysteroscopy, and uterine ablation). My doctor gave me a shot of Lupron to prepare my body for the surgery. I had to ask for information regarding the drug as none was offered. One side effect stated was increase in depression, which concerned me because I am on anti-depressants. I talk to my psych med doctor and he didn't seem concerned. Well, I immediately had symptoms of forgetfulness and confusion. My depression increased significantly (I cried for six days straight), I could not function normally, I broke up with my boyfriend whom I love very much because I thought my world was coming to an end, and on and on, migrane, hip and pelvic pain, weakness, sleeplessness, lack of appetite. Two weeks after the injection I am finally starting to come to reality and trying to fix the mess I made emotionally. Apparently, there was a medication I could have been given to counteract or lessen some of these side effects, but no one bothered to tell me. My advise, if you are feeling any side effects, contact your doctor immediately. I"m only glad I only had to have one shot and would NEVER get another.