I just finished my 10 day cycle of sulfameth/trimeth for a sever sinus infection - I have barely been able to eat the whole time - forcing myself to when I started to feel too weak - i love food and it has not appealed to me. I have felt nauseus and like there was a granite slab sitting in thepit of my stomach. I have also been extrmeely moody - just thought that was from lack of eating. Definitely dehydrated. Been getting leg cramps the whole time and one day I couldn't touch the skin on my right calf - i thought I had caused nerve damage from a short jog on the beach, but it was gone the next day. Then, lo and behold, on today, the last day, the nausea is still there, I feel tired and my back is really sore and I am covered head to toe in a really ugly rash. SOund familiar? I was told that there were no side effects to this drug except for dehydration. THis is first first time I have taken antibiotics in 10 years and I am not happy with the decision, but was so desparate.