I've been taking remeron for about 3 months and I have gained 15-20lbs. It increased my appetite especially at night. I would have an intense cravings for sweets, and it seemed like I never would get full. I hate this, everyone keeps asking me why am I gaining so much weight. I tell them its the remeron, and they all think I should just stop taking it, but it's not that simple. I've been struggling w/ extreme insomnia and depression for 2 years, with little or no relief from many other meds. It helps me sleep most of the time, but I don't know if it's really helping my deppresion. I'm going to speak w/ my doc about trying something else because I can't stop gaing weight, and that makes me even more depressed.