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My significant other took Doxycylene, 100 mg, twice a day for two...

Posted at 5: 0 PM on Sep 19, 2006 by rod.sulte, #17311
My significant other took Doxycylene, 100 mg, twice a day for two weeks to treat a swollen lymph node under his arm. During the treatment he experienced nausea, stomach pain, rash and cold sweats, nothing too bad. 3 days after the last dose everything got significantly worse. It started with sever chest pain, so bad we went to the emergency room thinking it was a heart attack or blood clot. They found nothing and discharged him. Over the next 3 weeks he started vomitting, diahrea and developed jaundice. Constant queeziness and chest pain. After numerous tests, ultra sounds, MRCP, the doctor has ruled out various hepatitas's and every other disease he could think of. He's also rulled out any kind of bile duct blockage after the MRCP. Its now been 7 weeks since all this started, my friend has dropped 40 lb's (190 down to 152) and still dropping. Our doctor (gastro interologist) has admitted he's stumped and is currently contacting a professor in Miami as a last hope. The only thing our doctor keeps comming back to is the Doxycyclene and that my friend may have had that one rare acute reaction. We're frazzled and don't know what to do next.
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Reply 7 months ago on Jan 27, 2008 by bob76, #4400

Hey,

I am experiencing similar symptoms as a side effect to taking doxyclcline hyclate mg for three months to treat acne. Now i have started to feel constant chest pain. I would like to know what was the result in your spouses case. It would be helpful to know since i am out of the US at the moment and cannot rush back to avail better medical facitlities and you seem like a similar case.

It would help to share your experience.

Thanks!!
Bob.

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Reply 3 months ago on May 17, 2008 by rod.sulte, #8366

My applogies for not responding to replies and private emails. I'm just now starting to get my life back together. My significant other passed away this past November (2007). Around March/April of 2007 he finally started recovering from the "cholestasis". The doctors (and we had *many*) never found the definative cause and it was left as caused by an "idiosyncratic reaction" to the Doxycyclene. The jaundice started to fade and he was able to start eating small amounts of food. But the lump under his arm also came back (this was the reason for taking Doxycyclene in the first place) and we had it biopsied. Turned out to be Hodgkin's Lymphoma. We were told he was in the 95% curable range. He immediately started chemo but in his extremely weakened state, it was just too much for him. He developed a lung infection from the chemo, so more anti-biotics (not Doxycyclene) and the jaundice and high bilirubin came back. His lungs got much worse and we were back in the hospitals by Sept/Oct and finally ended up in the Mayo clinic in Jacksonville. But it was too late, in his weakended state he developed a host of other conditions and asked to be taken off life support in November. This past year was an absolute nightmare and its hard for me even to write this down. If it hadn't been for the cholestasis, I truly believe he'd be still here.

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This registry is a place to share positive or negative side effects of using Doxycycline Hyclate. If you directly experienced a side effect while using Doxycycline Hyclate, then we encourage you to enter it here. Please note that entries here are the experiences of individual users, and in no way means that you or anyone else will experience the same side effect, since the same medication affects people in different ways. Please always contact your physician.
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