I have been getting the 7.5mg injection once a month since July 2006. I had a uterus the size of a 5 month pregnancy and have several fibroid tumors. My uterus has shrunk (not sure about the fibroids) but I have been having so many side effects I don't know if I would do this again if someone told me about them. Thankfully my last shot was Sept 8th and I will have a hysterectomy in October. I did lose the stomach but regained it with the weight gain!!!! My bones are always aching, constant teeth ache, headaches (mild migraines) every day. Now I have been experiencing dizziness and nauseous. I have been coming home from work the last couple of days because of this. I am so tired all the time - I take a nap during my lunch hour to just get through the day. Oh and the memory loss is so difficult for me. I cannot even remember co-workers names. I can't remember what I was supposed to do when I get across a room. I have to set a timer to remind me that I am cooking dinner!!!! I would definitely not recommend Lupron for any long time use. If my doctor told me that I would have to get another shot - I would say NO!!!!