I am alright when I take 500mg of Niaspan at bed time but if I in...

NOT an allergic reaction OR a "cardiac" raection,.. it IS temporary & it is PROSTAGLANDIN !! Try this,...
Not a big deal. ~90% of ALL patients can tolerate niacin 1-2 gms/day,.. IF,.. the prescriber knows a few tricks. Dr. Wm. Castelli , he uses plain ole crystalline niacin AND Niaspan. 40 years ago, ALL they had was IR-Immediate Release aka plain ole crystalline niacin,.. 3-4 gms a day MONO therapy. The patients FORGET HE ASPIRIN which prevents the flush. If you forget to take an aspirin AT LEAST 30 min before dosing,.. FLUSH! aking with the dose is too late. SOLUTION 4o YEARS AGO? Alka-Seltzer ; that`s a 325 mg of AQUEOUS aspirin, no need to take sooner,.. wash down the niacin with that. AFTER,.. you eat 3 TBS applesausce while ALKA-SELTZER tablet dissolves. use just enough water to swallow pill, so you get all 325 mg. 90% of patients get through the 'rough' 1st 2-4 weeks & stick with it after. IT IS THE ONLY DRUG WITH AN FDA INDICATION TO HAVE BEEN PROVEN TO REVERSE CAD, REGRESSION.
Remember; hot drinks, alcohol, spicy food less than 2-3 hrs prior to Niaspan is a NO-NO !!
Take care,.. ...be well... Steve the Lipid Guy