I've taken it several times and have had severe joint pain each time starting after about 3 days. The pain gradually goes away, but it takes close to 6 weeks. It took awhile to associate the joint pain with the Levaquin, but after figuring it out, I started putting on my medical charts that I'm allergic to it. While taking it, though, the joint pain was so bad that I could barely get up and walk and had to hold on to something to get from place to place. Driving was out of the question.