I've been taking Topamax for just slightly over two months to treat migraines and neuropathy and it has helped with both. My dr. also thought some of the side effects might be beneficial (i.e., wakefulness, weightloss, etc.). I wasn't prepared for all the negative side effects. I'm constantly thirsty (but everything tastes so bad I can't find anything to drink and I don't drink soda - so that's not the problem), I've have had a sore throat for the past two - three weeks, my tongue also burns and has streaky, red craters running over it. I'm incredibly crabby and my sex drive (which has never been a problem, is non-existent). I also seem to be craving sweets - maybe because they seem to be the only thing that tastes good. I'm currently taking 50mg 2x per day and I'm going to talk to my dr. about cutting each dose in half. If that doesn't help then I'm going to have to stop this med.