I have been on and off of prednisone for the last 3 years- very high doses starting at 120 mg a day- the side effects are nightmarish- extreme weight gain, rashes, infections, moon face, mood swings- if there is a side effect i have had it. The good news is though the side effects are temporary and eventually the weight does come off. I have idiopathic anaphylaxis- also with known allergies to medicines, food and the enviroment. As much as I hate being on the drug- it has saved my life everytime- have faith things will get better- just surround yourself with a good support team-