I've been on and off Prednisone since I was a little girl. I'm 23 now and have been off of the terrible stuff for 10 months. Prednisone and I have a love/hate relationship. It did save my life several times when I was having chronic, lethal asthma attacks. I almost died several times.
I suffered much when taking the drug. I had every side effect known to man: sleeplessness though moderate fatigue, depression, anxiety, fast heart rate, increase blood sugar levels (I was even given insulin), moon face (didn't recognise myself), increased weight gain (20+ lbs), horrendous abdominal strechmarks, heartburn/acid relux (which I had to be medicated for in order to continue taking Prednisone), mood swings, muscle pain, bone pain (I now have osteoperosis), muscle weakness, hot flashes, increased sweating, pale yellow-ish skin, bad acne, and water retension. There may have been more side effects, I just can't recall all of them right now. Thank God I'm not on this stuff right now!