I've been taking the Advair 500/50 for a couple weeks now, and the side-effects i'm experiencing are hoarsness when speaking, insomnia, and chestpain. I do rinse my mouth and brush my teeth afterwards but still sometimes have the hoarsness voice. This medication is not suppose to cause weight gain even though it's a steriod because it only goes to the lungs not the bloodstream, i asked my pulmonary specialist. Not sure what's going on w/ people's expanding mid-sections on this website????