on day 4 of a 5-day dose of 750mg....I experienced intense shoulder pain in both shoulders---later diagnosed as impingement syndrome for which I need to do physical therapy in hopes of getting back to normal again! Also, weakness and pain in my hands and upper thighs...I cannnot unscrew a jar or open a door without pain. I am normally very active --aerobics, swimming(up to a mile 3x weekly), step, and walking....I can do none of the above!...I told my doctor to add to my chart ---no Levoquin!....the cure for my flu has been worse than the flu!....they should remove from market and/or highlight the muscular problems associated with the drug.