I took 100 mg Imitrex and it didn't touch the headache - 3 hours later took another and a phenegrin (sp?) and within a very short time could barely move - every muscle in my body and every joint hurt - I could barely walk - could barely even turn in the bed - I'm 53 and you would have thought I was 103. This lasted about 12 hours. This has happened to me the last two times I have had a migraine and took the Imitrex.