I took 100mg of Doxycycline twice daily for suspected Epididymitis. The first few days I followed the instuctions and didn't notice any side effects. One night though I woke up with incredibly painful heartburn. I think I may have taken the pill without enough water right before bed. After that I continued to take the pills and the side effects started to become worse. I had headaches, dizziness, loss of appeitite, and painful heartburn. My advice to anyone taking this medicine would be to follow the instructions and not take the pill right before sleeping. It has been two days since I stopped taking Doxycycline and the side effects still have not subsided.