The first time I took imitrx it was through a shot at the octors office and it was horrible, I felt the liquid go through my body and it felt like fire through my blood all over my body, It was very unpleasant...after a while the headache went away...the second time I took it, it was in a pill form and it was horrible as well, the burning sensation came again and it made my headache worse, after that i threw away the rest of the imitrex I had..I would not recommend it