I have been on Prednisone since May 2005 starting at 60mg. In the beginning my appetite was out of control and I was going 100 mph. I find that I cut myself easily, experienced significant weight gain, even though i work out 5 days a week. The acne on my back is also making me crazy, and like others I have noticed mood swings and I lose it easily. I am by nature a very quiet calm person. I am now down to 10mg, hoping to drop to 5mg. I can only hope that the acne and the weight gain start to diminish.