After the second day of taking Prednisone I noticed a dramatic difference. I was not in pain anymore from the inflammation. I thought it was a miracle drug, but with-in a week I started to gain weight, even though I eat a very healthy diet. I have been on Prednisone for almost 5 months and I cannot believe the amount of weight I have gained. I am now weaning myself off of it due to Doctor's instructions, and am experiencing anxiety and depression and the pain is coming back, almost immediately. Although it helped me tremendously in the beginning, I would definitely try another remedy before I ever take Prednisone again. They call it the "nasty drug" for a reason.