Wow am I glad I found this site! I had my thyroid destroyed in May and started taking Levoxyl at the beginning of August of this year. At first things were going well but after the dosage was increased I started to notice leg pain, numbness in my hands and feet as well as joint pain. I spoke with the doc and he said that it could be related to not having enough hormone and after blood tests revealed very high TSH levels, he increased. Since then the pain has worsened and I even went to my primary doctor who tested for Lupus and RA. I had none of these symptoms until I started the Levoxyl, not one! I feel relieved that others are having this experience too and plan to speak with the doctor about it.