I started taking maxide with atelolol (later) have been taking since 1988, have not had any side effects. It works well. Lots of urine making. You people need a shrink, you must all be hypochondriacs! If you think something is wrong ASK YOUR DOCTOR!!! For Gods sake why take it for years and think it is hurting you. If my urine was blue or green I would admit my self to the phyc ward. And the muscle cramping. Well, ya know if you are producing a lot of urine, you are also loosing some potassium and you betcha' your legs and feet will cramp. And if you have nothing better to do take a spelling course.