I was on Topamax for 3 weeks, and only got up to 75mg/day before insisting to be taken off it. I felt drunk all the time, couldn't concentrate or find the right words, my hands and feet were numb and tingly all the time, I had awful heartburn/belching for almost 3 weeks straight, I couldn't sleep, and was very nauseous all the time. I may have stuck it out a bit longer, but I had 5 migraines in 12 days, which was an increase in frequency compared to before taking the Topamax, so I didn't feel this drug was working for me. Today was my first drug-free day, and my head is so clear, it is just great! My feet are still tingly though, so I'm hoping that will go away soon...