I have been on Topamax for three weeks now. I have a genetic brain abnormality that causes severe and frequent migraines. Before being put on Topamax, I was experiencing at least one migraine a week lasting for NINE hours. They were unbearable. I am still working up to my full dosage of Topamax, but it seems to be working. My head is clearer than it has been in some time. At this point, I am experiencing some side effects including decreased appetite (though nothing that I couldn't afford to lose) and tingling in the toes and fingers. Of course these pale in comparison to the migraines that I have been rid of since I have been on the medication. I will repost later if I begin to have negative experiences.