I've taken Z-Pak only twice in my life. The first time I had a bad headache for the whole time taking it. The second time was horrible (probably worse because I didn't eat food with it this time)! I was in bed all day long with a severe migraine, vomiting, and feeling severely fatigued. Ive never felt like that before in my life. It was like my body was shutting down. I couldn't even eat anyting until late that day. I stopped taking it right away. Now I always ask for amoxicillan.