My dermatologist prescribed Sulfameth for a bacterial infection with manifested as a bad rash on my leg. After three days, the rash cleared. Since my doctor wanted me on a 21 Sulfameth cycle I still had to take it. After one week, I started to feel a little blue, like I was in a fog. I didn't immediately think it was the medicine. Then two days after I started feeling a down, I got really bad hives on my chest and arms. These hives wer of the pins and needles kind, not too itchy, but very distressing. I started having severe chills and my irratibility went through the roof. My neck and back were in pain. The day after that I called my dermatologist and he told me to stop taking the Sulfameth immediately. By then, the hives spread all over my body, and my eyes are completely bloodshot. I look like I have swelling and severe sunburn. At least I'm not as irritable and the chills are gone. When I had the chills it felt the same as going through nicotine withdrawal. Just ... AWFUL. Hopefully the rash will clear soon, so far it's only gotten worse.