I took Levaquin for 10 days for a sinus infection. On the sixth day, my knees began to ache. Since I stand all day at my job, I thought it was job-related. By the 10th day I had terrible pain in my knees and pain in my calf muscles. After 3 days of agonizing pain in my knees and calves, and having to hold onto to furniture in order to walk, I called the dr. to relay my symptoms. The nurse said it was a side effect of Levaquin. . .sore tendons, aching joints. When I asked if there was anything I could do, they said it would just have to work itself out of my system. They would mark it in my file. I asked how long the side effects would last. . answer. . .4 to 5 days. It is now 14 days since I took the last pill, and the pain is just starting to subside. However, I'm still having difficulty getting up after sitting, and have weakness in my knees. I am 63, have a little arthritis, and now feel this medication should not be given to anyone that has slight joint problems. The pain has been 10 times worse than any arthritis pain that I have had. I have stepped up my anti-inflammatory medicine in the last 5 days. This may be why the pain is lessening, also. I agree that if I had been able to read the side effects warnings before paying for this prescription, I never would have taken it. I just hope these side effects are not permanent. You are always told to finish your medicications. . .however, in this case, I wish I had.