I was on Lupron for endo 4 and 5 years ago, two times. The second time without add back therapy. I started migraines at that time and basically had them for 2 years almost non-stop. I am ultra sensitive to estrogen level. I also had joint aches, night sweats, and severe depression. I finally had a hysterectomy two years ago and got rid of my migraines with a nice steady dose of estrogen. I can't lose the weight. I still have joint pain.