Oh my God! The itching is horrible! I woke up and my eyes crossed from the severity. I could not even go to work. After taking Sufameth/trimethoprim for 2 days (2 pills/da) for a UTI, my scalp started to itch. I scratched all day with a pencil...to no avail. Later that day, the vaginal and rectal itch was unmerciful. Vagisil maximum COULD NOT TOUCH it. I scheduled a gyne appointment because I thought, maybe I was developing something else...yeast infection. But there were no other signs. My husband suggested it could be an allergic reaction to the medicine. My nurse suggested I take an antihistimine like Benadryl. That provided some relief. Now I see similar postings on the web about severe itching. Thank goodness I only have one more pill of this 3 day treatment.