I have taken three 500mg doses and have experienced a rash(Like Poison Ivy) on my face as a result. I am taking Toporol XL100mg and Lipitor 20mg also. However, these have never caused any problems. The Leviquin was for other infection Sinus/Kidney related. The infection seems much better but I will have to change to another antibiotic. I seem to be one of very few people that break out in rash.