I was on 50 mg Toprol for about five months when pressure went up...doctor put me on 100 mg. During the 50 mg time, I did gain some belly weight, extreme swelling of the ankles, and a feeling that my heart was beating too fast even though it wasn't. When I went to the 100 mg pill, within a week I have a rash all over...bumps that itch like crazy. I have noticed more chills...then a feeling like a hot flash. I am weaning myself off...four days of 50 mg, couple days of 25 mg, and now I'm even splitting that. My doctor told me to go right to another drug...Zestril. I'm going to try to wait a few days. Even though I am tapering off of Toprol, the rash is still here. Maybe it takes awhile for the Toprol to be completely out of system.