I seem to experience extreme irritability and headaches after just a couple days of taking this medication. I have tried it before but stopped taking it because it made me feel so bad. The doctors have again prescribed this medication at 75 mg for hypothyroidism and he says that he does not think it is the Levoxyl causing these side effects. Maybe it is just my imagination but I swear I get real irritated and even depressed shortly after starting this medication. I am on my second day now and again I am experiencing these side effects. I wonder after a period of time will the side effects decrease.