My 16 year old daughter is taking Topamax (50 mg. in the a.m.) along with 15 mg. of Adderall as a mood stabilizer because the Adderall makes her agitated. The Topamax made her even more aggitated and guess what? The doctor increased the Topamax to an additional 25 mg. in the late afternoon and told me I need to try this for two weeks. Now my daughter has a "meltdown" every 15 minutes and can get quite violent. Topamax worked well on her before puberty, since then, it's a nightmare!