Typically when I have used Prednisone in the past, I've taken it only for a short time (5 days at most of 20-30 mg). As for a side-effect for me, it's only been POSITIVE! I have manic-depression, and this stuff elevates me. In fact, it can steer me to become increasingly euphoric even after stopping it after just a few days. I know for a fact as a 46 year old having mania and depression for 10 yrs and seeing many doctors, they would all rather see someone semi-depressed (meaning more managable for them), than too euphoric. I then take more lithium to bring me down before I get too out of control. Just do a google search on "predinisone depression". You will know what I mean. Also, this of course won't work for everybody. I'm explaining my own observations. And certainly long term, it will have it's side effects. Find sth. else if it bothers you. Every drug has it side effects, and sometimes they include the GOOD. www.intrepid.ws