Weight gain, joint aches, knee pain, insomnia, irritability, depression...and the tests come out okay. So what is wrong with me? Why do I continue to gain so much wieght and the fatigue is horrible! Over the past five years it has snuk up on me but now I am thinking this Singulair is the culprit. I haven't had as much trouble with my asthma ...true...but I feel horrible. I am going back to using Advair as needed and my albuterol as needed. Goodbye Singulair!