I am a 47 yr. old female. I have been taking Advair 250 for several months and have been sick for about 2 of the them. I get a flu-like feeling once a week. I cannot move. I also have trouble sleeping, sore throat, headaches, ear pain, weight gain, all of which I was not experiencing prior to this medicine. It took me a while to figure out what was bothering me. I am going to the doctor this week to change this medication.