Im gina from Delaware, I started colazal last Oct. of 2006. My insides feel brand new.I have my energy levels back and moving again, like 15yrs earliar. Im very happy. I'll be on this medication for three years. Im surprised I wasnt given it sooner. And to the people above, if you have breathing trouble you shouldnt be on it. Thats what I was told! Take care best wishes.