I was taking ortho-tri cyclen for 1 year with no problems, but switched to Yasmin on the recommendation of my dermatologist, because it has been known to clear up acne in some women. It has been just about one month; I only have a few active pills left and I am definitely going to switch back to ortho-tri cyclen. I have experienced awful mood swings and not to mention, my skin actually got worse! But the mood swings are by far the worst part-- I feel like I want to cry ALL the time, in fact there have been many mornings on my commute to work when I actually have cried-- for no real reason! Also, I feel extremely edgy- I feel angry all the time and the slightest thing irritates me (prior to this I have always had a relaxed, easy going personality). It dawned on me this morning when I realized I was muttering curse words to myself that there is a big problem! I have also noticed I haven't been able to focus at work. I hope that other people can recognize side effects they are experiencing and make the change too. Good luck!!