I have been on Advair 250/50 since it was allowed in the USA. I also take Spiriva. I told my pulmonary doctor last October that I would like a lower dosage. Now I am on 100/50. The side effects have not dimished and I am getting scared. My skin has aged and the forearms are like goosepumps. Just diagnosed with cataract in one eye and I was told I have severe osteoporosis. I have COPD, the reason for taking Advair. I now have HIVES. I do not suggest anyone try Advair. It is a killer. Tomorrow I have an appointment with my regular doctor for the hives and I am going to inquire about getting off Advair. I don't know if I need any other medication? I use oxygen at night when I go to bed (concentrator). When I was working I didn't need the oxygen during the day but I know I have a lot of anxiety which leads to depression. I have small canisters of oxygen in case I need it. When I get upset, I can use it but notice I recover on my own.