I have been using topomax 100mg daily for 6 months now. I started at that dose immediately, as I was having occular migraines on a daily basis. I experienced terrible side effects of memory lapses, tingling in my face and hands, & speech issues for about 6 weeks. It was about that time that I also realized carbonated beverages were tasting like liquid tin. I also have decreased appetite, and have lost 35 lbs. The side effects were awful in the beginning, but I was told they would subside after my body adjusted to the medication. So, I kept telling myself the effects were due to the medication, and would eventually go away, and they did. I have to admit, those 6 weeks were awful. My kids, hubby and I would joke, because Mom just had a "loopy" topomax moment. As of today, the only side effects are the liquid tin taste of carbonated beverages and loss of appetite, and I am now experiencing difficulties sleeping, which could be caused by something else. For me, the 6 weeks of feeling like I was losing my mind were worth going through, as I am continuing to lose some needed poundage, and most importantly, I am headache free!