I've been taking toprol xl 50mg once a day for a couple of years now for "hypertension" along with atacandHCI 12.5 mg . I have gain A LOT of weight and it is very unusual! I was a vol. wrestling coach for 20 yrs. so I stayed fair to very active. I also work all day in my business as a jeweler so I don't get around as much lately. After reading posts on this sight, I am CONVINCED that My meds. are the majority to blame! I get edema if i don't watch the salts, but I took a bunch of copies from this sight to my Dr. and he about called me CRAZY! This weight problem didn't start until I took this stuff. I also am experiencing sleeplessness, frquent trips to the bathroom at night ( probably from the diuretics I NOW have to take), tiredness, and overall lack of energy. I will be seeking a second opinion about my meds and condition and will up date afterwards. STAY AWAY FROM THIS MEDICINE!!!!