I have confusion.Difficulty speaking certain words.Memory seems a...

I have had the same experience with estradiol and other similar HRT meds. I have also had a lot of swelling in my calves too. I also found out the hard way that these medications can cause gallbladder disease. I had mine removed in Dec after three years on Cenestin. Nouns are hard to articulate and my memory is awful. I have been dosing off of it and hoping to do something natural. I had a total hysterectomy though so it has been hard to find something else that is adequate replacement.