I have had the same experience with estradiol and other similar HRT meds. I have also had a lot of swelling in my calves too. I also found out the hard way that these medications can cause gallbladder disease. I had mine removed in Dec after three years on Cenestin. Nouns are hard to articulate and my memory is awful. I have been dosing off of it and hoping to do something natural. I had a total hysterectomy though so it has been hard to find something else that is adequate replacement.
This registry is a place to share positive or negative side effects of using Estradiol. If you directly experienced a side effect while using Estradiol, then we encourage you to enter it here. Please note that entries here are the experiences of individual users, and in no way means that you or anyone else will experience the same side effect, since the same medication affects people in different ways. Please always contact your physician.
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