I've been on it for almost three weeks now and I have noticed more extreme depression. I already suffer from clinical depression. At first I thought maybe ti was just me, but after being on nuvaring this long, I feel I am a lot worse off in the depression department. It is a shame, because I am taking it for severe PMS, complex ovarian cysts, and painful menstruation. I am also having more severe headaches and my chronic pain from TMJ and Fibromyalgia has increased. I am waiting to see if I feel any better during the week it is out. It says on their web site that women prone to depression might need to stop taking this so it can cause depression.