My mom has been on predisone off and on for the last 19 years. First for asthma for 5 years weight gain of 100 pounds. then got off of it by going to national jewish hospital in Denver. Still put on it over the years Now the last year has been diagnosed with sjogrens syndrome and put on predisone as well as methotrexate injections. They started coming down and she had some heart trouble so back up and she kept telling drs her chest hurt all the way to her back this went on for 6 months 6 times in hospital and ER they kept saying it was her heart and rib cage. Well finally 10 days ago finally took a back exray and she had three fractures in her spine. So she has had a broken back for the last 6 months which was caused by the predisone. Had surgery 4 days ago but is now in nursing home for a while and the sjogrens is showing up in her lungs and was told this week that the treatment is predisone. She has so many things wrong that I now feel like the predisone has probably caused most of her health problems. Predisone should never be used for long term use it is to dangerous and so very painful.