I have had GERD for 3 years, and I took Nexium to treat it for the first 2 years... worked great, could eat whatever I wanted (I love spicy food!) with no side effects. My insurance stopped covering Nexium, so I began to take Aciphex as both my mother and grandmother have taken it for years (GERD runs in our family). In the last week, I have had a sensation like a huge lump in my throat, and the feeling that I could not take a deep enough breath. Since I have dealt with anxiety in the past, I thought it must be that... however, I noticed that I was burping much more than usual and when I wasn't burping, I felt like I needed to but couldn't. I have felt miserable, and thought something was really wrong with me. Tonight, I found this site and another of people complaining of the experience I am having. I am not taking Aciphex for the rest of the week and will see how I feel. I hope that the way I feel is due to the side effects of this medicine! I will pay out of pocket for Nexium, b/c the way I feel no is unacceptable. My mom and grandmother have never had these problems, however, medicine affects all people differently... I just don't think Aciphex and I go together.