Started 50 mg Topomax a week ago and to help lose weight gained from my lithium. I'm already on a mood stabilizer lamictal so I didn't need it for mood - only appetite suppression. The first day I did notice that my taste for diet sodas changed - I thought something was wrong with the can and threw it away and got another, but no, it was the same. Oh well. My appetite is pretty much zero, which is fine with me since I gained over 30 pounds since starting lithium seven months ago. I don't feel any tingling or any wierd sensations - but I did feel lethargic/"stupid" the first day (and I'm definitely not that!) - so I switched to taking it at night only and that took care of that. I still feel tired when I take it at night and a little slow in the morning but by the time I get to work I'm good to go. As far as how I'll do when my psych ups the dosage I'll have to see - I'll be sure and post. I think everyone tolerates meds differently and you need to research any drug before you take it.