I have been "self-medicating" with Seroquel for more than 4 years. I often take just 50 mg to get me to at least fall asleep for a couple of hours. When I tale the 100 mg tablet I sleep better for almost a whole 6 hours! I am a victim of my own distruction though; I drink coffee in massive quantities and smoke heavily. I do not have the weight gain but do have the surreal dreams and often a lower back ache which I normally atribute to the crummy mattress I sleep on. My main problem i; I start my regimine of meds and stop when I think I am better. I end up losing any job(s) I have and have to restart the drugs all over again. My doctor's have found a mix of epival (divol-proex) 1500 mg, for mood swings and the Seroquel should help my depression and bi-polar. I assume if I ever manage to stay on them both long enough to actually have a full affect I could be more helpful in suggesting this regimine to others. But a viscious circle starts with the drugs, when you are covered by any disability plan the drugs are accessible; but when you start working and exceed a certain income, the drug plan stops and becomes too costly to buy.